In a few days, I'm going to start on a major rip project from DVD to m4v. This is to specifically play back on a Roku as I've experienced nothing but inconsistent problems when trying to use ISOs with Plex Media Server and the Plex channel. Some play, some don't. I'm planning on using handbrake for the conversion using the "Normal" setting but it defaults to the .m4v file extension and was wondering if anyone can brief me on the advantages of possibly using .MKV over .M4V? Any other suggestions would be great as I only want to do this once. 
Hey, many thanks in advance.
p.s. One more thing... I'm ripping a TV series and as everyone probably knows, each DVD contains about 4 shows in their own seperate tracks. Can anyone recommend a tool that I can rip those individual tracks from the DVD in batch mode putting each show in an ISO or directly to m4v/mkv? I'm hoping to set it up and let it run overnight. I'm using DVDShrink but have to do one at a time manually and is really a pain.
I done many TV Shows and this is what I do:
1. I use MakeMKV to rip the shows (yes, you have to check/uncheck each epiosde for ecah disk (audio tracks, subtitles, etc.), but it works well.
2. IF space is NOT a concern, then I'd leave them in MKV format. Name each episode using the suggesting Plex naming convention. Since I do have a concern about how much space I'm using, I then group all the episodes in one folder. Then as an overnight or during the day while at work, I'll drop that folder in Handbrake and convert each episode to m4v.
3. Plays fine on the Roku
EDIT: wanted to add that I have mine converted to m4v so I can watch content on my ipad or appletv2, in addition to the Roku. Just depends what room I am in.